Inhibition of β-amyloid1-40 Peptide Aggregation and Neurotoxicity by Citrate
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چکیده
منابع مشابه
Inhibition of beta-amyloid(1-40) Peptide Aggregation and Neurotoxicity by Citrate.
The accumulation of beta-amyloid (Abeta) aggregates is a characteristic of Alzheimer's disease (AD). Furthermore, these aggregates have neurotoxic effects on cells, and thus, molecules that inhibit Abeta aggregate formation could be valuable therapeutics for AD. It is well known that aggregation of Abeta depends on its hydrophobicity, and thus, in order to increase the hydrophilicity of Abeta, ...
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Insertion of an anthranilic acid in an amyloidogenic peptide sequence generates a novel conformationally restricted α/β-hybrid peptide that inhibits amyloid formation of Aβ(1-40) and disrupts preformed fibrillar aggregates in vitro. Such β-sheet breaker hybrid peptides (BSBHps) may be useful for designing novel physiologically important compounds relevant to diverse amyloidoses and for studying...
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Alzheimer's disease (AD) is characterized by the abnormal aggregation of amyloid-β peptide (Aβ) in extracellular deposits known as senile plaques. The tyrosine residue (Tyr-10) is believed to be important in Aβ-induced neurotoxicity due to the formation of tyrosyl radicals. To reduce the likelihood of cross-linking, here we designed an Aβ-40 analogue (Aβ-40 Y10F) in which the tyrosine residue w...
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SPECIFIC AIMS We have examined the hypothesis that small molecular weight compounds capable of inhibiting the aggregation of the beta-amyloid peptide (Aβ) could protect neurons from the toxic effect of Aβ and prevent cerebral amyloid deposition. The anti-aggregating and neuroprotective effects of nitrophenols were investigated in vitro using primary cultures of rat hippocampal neurons, and the ...
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Amyloid beta-peptides (Aβ) are known to undergo active transport across the blood-brain barrier, and cerebral amyloid angiopathy has been shown to be a prominent feature in the majority of Alzheimer׳s disease. Quercetin is a natural flavonoid molecule and has been demonstrated to have potent neuroprotective effects, but its protective effect on endothelial cells under Aβ-damaged condition is un...
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ژورنال
عنوان ژورنال: The Korean Journal of Physiology and Pharmacology
سال: 2009
ISSN: 1226-4512
DOI: 10.4196/kjpp.2009.13.4.273